LONDON — A 48-year-old man from Bedfordshire, UK, has become the first patient in the world to have a brain tumor successfully removed while medical teams utilized real-time artificial intelligence during surgery.
Surgeons at the National Hospital for Neurology and Neurosurgery (NHNN), part of University College London Hospitals NHS Foundation Trust, operated on Rhys Hibbert using novel technology that helps identify minuscule brain anatomy by color coding, or segmenting, crucial structures to help clinicians recognise them safely.
The hospital has been using the technology as a research tool for some time, but the operation conducted in May marked the very first occasion it has been used on a live patient.
Hibbert, a father of two, could have lost his sight without the operation, said surgeons at University College London Hospital.
The AI tool analysed a video feed of the operation as it happened and advised surgeons on how to avoid crucial but hidden vessels and nerves in the brain. It allowed them to safely remove as much of the tumour as possible.
“From a patient safety perspective, I can see absolutely the benefit. There are no road signs inside our head,” said Hibbert.
Until 18 months ago, Hibbert, a customer services manager, was fit and healthy, going on a two-mile walk every lunchtime.
It was on one of these walks that he fell unconscious and started fitting in the road.
A brain scan revealed he had an 11mm (0.433in) non-cancerous tumor growing on the pituitary gland, a marble-sized organ at the base of the skull.
The gland secretes vital hormones that help with processes like growth, metabolism and regulating blood pressure and temperature.
Crucially, it sits very close to the carotid arteries, which are vital vessels that supply blood to the brain, and the optic nerves that control vision.
As Hibbert’s tumor began to press on his optic nerves, it narrowed his peripheral vision.
Although he didn’t need surgery straight away, Hibbert started to trip over things and felt severely fatigued and dizzy.
“For 18 years of married life I’ve always got out of bed and made my wife a cup of coffee,” Hibbert said, “and I wasn’t going to let this tumor stop that.”
He said the biggest impacts for him were emotional and psychological.
“Though I had a lot of people kindly offering help, you don’t want to be a burden on people,” he added.
When surgeons gave him the option to be the first person to try the operation with their bespoke AI tool involved, he didn’t hesitate.
“If patients are not prepared to join research how can doctors ever learn and how can medicine ever progress?” he said.
The surgery involved inserting an endoscope – a thin camera on a stick – via the nose to the base of the skull.
At this point the tumour was close but hidden behind layers of bone and tough membrane.
Identifying the safest place to extract it was not straightforward, particularly as anatomy tends to differ between individuals.
Complication rates vary but there was a 25-50% chance of not getting the whole tumour out and a 0.5–2% chance of injuring a major blood vessel.
This is where the AI tool came in.
On a second screen, it analysed the live video feed, tracked the surgical instruments, and marked up areas where the vessels and nerves were most likely to be, highlighting areas where it is safest to remove the tumor.
It is similar to facial recognition technology on phones, but recognises important and often hidden anatomical structures instead.
The average UK surgeon performs about 10 to 20 of these operations a year, relying on scans done before surgery to familiarize themselves with the patient’s anatomy.
Researchers trained and evaluated their AI system on hundreds of videos of pituitary tumor removals, carefully drawing around the vessels and nerves on each video to help the system capture data and begin to “recognize” the most important structures.
“It is trained on more operations than most surgeons see or do in a lifetime and can act like an expert second pair of eyes,” said Prof Hani Marcus, who helped carry out the procedure.
And unlike other experimental AI tools, it works in real time, he added.
The team wants to make clear that the AI tool is just assisting and the surgeons retain full control.
Their long-term ambition is to develop a type of ChatGPT for surgeons, so there can be “another expert in the room they can turn to for advice if they want it, or leave if they disagree with it,” said Prof Marcus.
Funded by the National Institute for Health and Care Research and Google, the team tried and tested their AI technology in the lab for years.
They are pleased with how the first steps have gone in real-life surgery and are working on a larger trial.
“When I opened my eyes after the operation, it felt like I had got 360-degree vision — I hadn’t seen that clearly for a year,” said Hibbert.
And in the eight weeks since surgery, he has noticed his sight improving every few days.
“I also have my energy back and all of the side effects I was suffering before surgery have gone.
“It’s given me my life back.”
Source: Saudi Gazette